Heretic

For people who want to live fully, without giving up rigor

Beyond conventional medicine, with the evidence in hand

We go where mainstream medicine rarely looks and hold every claim to the same standard. Each one is traced to its sources and rated, so you can see what’s proven, what’s promising and what’s still speculation.

Asked often Has BPC-157 been tested in humans? Rapamycin for aging Does red light therapy work? Semax vs Selank
Every claim tracedHonestly ratedInforms, never prescribes

Where the mainstream rarely looks

Select a field to filter the index

Index

146 of 146 entries
#
40 Hz gamma sensory stimulationCognitionTherapyEarly
A
AdaptogensCognition · Trauma & stressCompoundPromising Advanced glycation and crosslink breakersAgingMechanismSpeculative Alpha-GPC and citicolineCognitionCompoundPromising Alpha-ketoglutarate (AKG)AgingCompoundEarly AutophagyAgingMechanismProven
B
Biofilms and chronic infectionChronic infectionMechanismSpeculative Biohacking and optimizationAging · Metabolic health · CognitionGuideSpeculative Biological age clocksAgingMeasureProven BPC-157Injury & recoveryCompoundEarly BrainspottingTrauma & stressTherapySpeculative BreathworkTrauma & stressTherapySpeculative BromantaneCognitionCompoundSpeculative
C
Carnivore dietMetabolic healthDietEarly CerebrolysinCognitionCompoundEarly Chronic sinus and gut biofilmsChronic infectionConditionSpeculative Cold and heat therapyInjury & recovery · Metabolic healthTherapyEarly Creatine monohydrateCognition · Injury & recoveryCompoundPromising
D
Daily multivitamin (COSMOS)Cognition · AgingCompoundPromising DAO and histamine degradationChronic infection · Metabolic healthMechanismEarly Darkfield microscopyChronic infectionMethodSpeculative Dental biofilmsChronic infectionConditionPromising DihexaCognitionCompoundSpeculative DMSOInjury & recoveryCompoundSpeculative
E
Electromagnetic therapies (PEMF)Injury & recoveryTherapyEarly EMDRTrauma & stressTherapyProven EpitalonAgingCompoundEarly Exercise and longevityAging · Metabolic healthGuidePromising Exosome therapyInjury & recovery · AgingTherapyEarly
F
FastingMetabolic health · AgingDietPromising Fasting-mimicking dietMetabolic health · AgingDietPromising FDA peptide reclassification 2026ReferenceRegulatorySpeculative Flmodafinil, fladrafinil and adrafinilCognitionGuideSpeculative Frequency-specific microcurrentInjury & recoveryTherapyEarly
G
GHK-CuInjury & recovery · AgingCompoundPromising GLP-1 agonistsMetabolic healthCompoundProven GLP-1 drugs and muscle preservationMetabolic healthGuideEarly GlyNAC and glutathione precursorsAgingCompoundPromising Growth hormone secretagoguesMetabolic health · AgingGuideEarly Gut health and SIBOChronic infection · Metabolic healthConditionSpeculative Gut microbiome and postbioticsMetabolic healthMechanismEarly
H
Hallmarks of agingAgingMechanismEarly Heavy metals and chelationChronic infectionTherapyEarly Herniated discs and low back painInjury & recoveryConditionSpeculative Hormone optimization (TRT, HRT)Aging · Metabolic healthTherapyPromising Human nutritionMetabolic healthGuideSpeculative Hyperbaric oxygen (HBOT)Injury & recovery · CognitionTherapyPromising
I
IFS (Internal Family Systems)Trauma & stressTherapySpeculative IHHTAging · Metabolic healthTherapyPromising Immune functionChronic infectionMechanismSpeculative Industry funding and trial resultsReferenceMethodProven
K
Ketogenic dietsMetabolic health · CognitionDietPromising KlothoAgingMechanismEarly
L
Lion's mane and mushroom nootropicsCognitionCompoundPromising Longevity medicine in 2026AgingGuideEarly Longevity scienceAgingGuideSpeculative Low-dose colchicineAging · Metabolic healthCompoundPromising Low-dose lithium and Alzheimer'sCognition · AgingCompoundEarly Low-dose naltrexone (LDN)Chronic infection · Trauma & stressCompoundSpeculative Lyme and co-infectionsChronic infectionConditionSpeculative
M
Magnesium formsCognition · Metabolic healthCompoundProven MCAS and histamineChronic infectionConditionPromising MCAS claims audit (Andra Sitoianu)Chronic infectionGuideEarly MCAS diagnostic criteriaChronic infectionGuidePromising MCAS drivers and comorbiditiesChronic infectionGuideEarly MCAS interventions evidenceChronic infectionGuidePromising Metabolic health and insulinMetabolic healthMechanismSpeculative Metformin and rapamycinAging · Metabolic healthCompoundEarly Methylene blueCognitionCompoundSpeculative Mexidol, bemethyl and phenylpiracetamCognitionGuideEarly Microplastics and PFASAging · Metabolic healthConditionEarly Mitochondrial healthAging · Metabolic health · CognitionMechanismPromising Modafinil and eugeroicsCognitionCompoundPromising Mold illness and CIRSChronic infectionConditionSpeculative MOTS-cMetabolic health · AgingCompoundEarly MSC exosomes for orthopedic repairInjury & recoveryTherapyEarly mTOR and AMPKAgingMechanismSpeculative Muse cell therapyInjury & recoveryTherapyEarly
N
NAD+AgingCompoundPromising Natural nootropicsCognitionCompoundPromising Nicotinamide for skin cancer and glaucomaAgingCompoundPromising Nicotine as a nootropicCognitionCompoundPromising Noopept (omberacetam)CognitionCompoundEarly Nootropic combinations studiedCognitionGuideSpeculative Nootropics and smart drugsCognitionGuideEarly
O
Off-patent compounds and missing trialsReferenceMethodPromising Omega-3 and biological agingAgingCompoundPromising Organ meatsMetabolic healthDietSpeculative Ozone therapyChronic infection · Injury & recoveryTherapyEarly
P
Pain managementInjury & recoveryGuideSpeculative Partial epigenetic reprogrammingAgingMechanismSpeculative Peptide bioregulators (Khavinson)AgingCompoundSpeculative Peptide evidence gradingReferenceMethodSpeculative Peptide gray-market enforcementReferenceRegulatoryEarly Peptide sources and qualityReferenceGuideSpeculative Peptides for injuryInjury & recoveryGuideEarly Peptides for traumaTrauma & stressGuideSpeculative Phage therapyChronic infectionTherapyPromising PhenibutTrauma & stress · CognitionCompoundEarly PlasmalogensCognition · AgingCompoundEarly Polyvagal theoryTrauma & stressMechanismSpeculative ProlotherapyInjury & recoveryTherapyPromising PRP and stem cellsInjury & recoveryTherapyPromising Psychedelic microdosingCognition · Trauma & stressGuideSpeculative Psychedelic-assisted therapyTrauma & stressTherapyPromising
R
RacetamsCognitionCompoundEarly RapamycinAgingCompoundEarly Red light therapyInjury & recovery · CognitionTherapyPromising Regenerative medicineInjury & recoveryGuideSpeculative Russian pharmacologyCognitionGuideEarly
S
Seed oils and inflammationMetabolic healthDietSpeculative SelankTrauma & stress · CognitionCompoundPromising SemaxCognitionCompoundPromising SenolyticsAgingCompoundEarly SGLT2 inhibitorsAging · Metabolic healthCompoundEarly Shingles vaccination and dementiaCognition · AgingTherapyPromising SleepCognition · Trauma & stressGuidePromising SLU-PP-332 and ERR exercise mimeticsMetabolic health · AgingCompoundEarly Somatic ExperiencingTrauma & stressTherapyEarly Soviet medical researchReferenceGuideSpeculative Soviet space medicineReferenceGuideEarly SpermidineAgingCompoundEarly SS-31 (elamipretide)AgingCompoundPromising Stealth pathogensChronic infectionConditionSpeculative SulforaphaneAging · Chronic infectionCompoundEarly Sun exposure and healthAging · Metabolic healthTherapyPromising Supplements and nutraceuticalsAging · Metabolic healthGuidePromising
T
TaurineAgingCompoundEarly TB-500 (thymosin beta-4)Injury & recoveryCompoundEarly TB-500 and BPC-157 togetherInjury & recoveryGuideEarly TelomeresAgingMechanismPromising The drug-exclusion ruleReferenceRegulatoryProven The sugar industry papersMetabolic healthGuidePromising Therapeutic peptidesInjury & recovery · AgingGuideEarly Therapeutic plasma exchangeAgingTherapyPromising ThymalinChronic infection · AgingCompoundSpeculative Thymosin alpha-1Chronic infectionCompoundEarly TianeptineCognition · Trauma & stressCompoundEarly Trauma and the bodyTrauma & stressGuideSpeculative Trials, observational studies and n-of-1ReferenceMethodProven
U
Ultra-processed food and nutrient declineMetabolic healthGuidePromising Urolithin AAgingCompoundPromising
V
Vitamin DChronic infection · AgingCompoundPromising Vitamin K2AgingCompoundSpeculative
W
What 36,000 nootropic ratings showCognitionGuideSpeculative Who funds nutrition researchMetabolic healthGuidePromising

Our standard

One standard for every claim, mainstream or not

Traced

Every claim links to the study, trial registry or regulator document behind it. If we can’t trace it, we say so.

Honestly rated

The same four-level scale for every entry, from proven to speculative. A popular idea with thin evidence is rated as thin.

Informs, never prescribes

We report what studies used and found. What you do with it is between you and your clinician.

How we make money

Some links earn us a commission. They’re labeled, they sit below the evidence, and they never change a rating. We don’t link to sellers of gray-market compounds.

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